Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Crhbptm1Afs
Name:	corticotropin releasing hormone binding protein; targeted mutation 1, Audrey F Seasholtz
MGI ID:	MGI:3513042
Gene:	Crhbp  Location: Chr13:95567884-95581339 bp, - strand  Genetic Position: Chr13, 49.5 cM
Alliance:	Crhbptm1Afs page

Germline Transmission:	Earliest citation of germline transmission: J:57963
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The translated portion of exon 1 and all of exons 2-5 were replaced with a PGK-neomycin resistance cassette. In situ hybridization confirmed the absence of transcripts in the cerebral cortex. (J:57963)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crhbp Mutation:	23 strains or lines available

Original:	J:57963 Karolyi IJ, et al., Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11595-600
All:	2 reference(s)