Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Htra2tm1Jdo
Name:	HtrA serine peptidase 2; targeted mutation 1, Julian Downward
MGI ID:	MGI:3512633
Synonyms:	HtrA2/Omi-
Gene:	Htra2  Location: Chr6:83028247-83031552 bp, - strand  Genetic Position: Chr6, 35.94 cM
Alliance:	Htra2tm1Jdo page

Germline Transmission:	Earliest citation of germline transmission: J:94227
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P/Ola

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neo gene replaced part of exon 1, exons 2 to 6, and part of exon 7 via homologous recombination, removing 83% of the coding sequence including the proteolytic catalytic site. Western blot analysis confirmed absence of protein in MEFs (J:94227)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htra2 Mutation:	19 strains or lines available

Original:	J:94227 Martins LM, et al., Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol Cell Biol. 2004 Nov;24(22):9848-62
All:	6 reference(s)