Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rr169tm2Rao
Name:	regulatory region 169; targeted mutation 2, Anjana Rao
MGI ID:	MGI:3512141
Synonyms:	HS IV-, Il4tm2Rao
Gene:	Rr169  Location: unknown  Genetic Position: Chr11, Syntenic
Alliance:	Rr169tm2Rao page

Germline Transmission:	Earliest citation of germline transmission: J:94039
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Modified regulatory region, Null/knockout) Mutation:    Disruption caused by insertion of vector   Mutation details: A loxP site flanked neomycin resistance gene cassette replaced a 1.9 kb section containing DNase I hypersensitivity site IV (HS IV), an Il4 silencer located between Il4 and Kif3a. Transient Cre recombinase expression removed the neo cassette in ES cells. DNase hypersensitivity analysis of mutant cells showed a loss of HS IV, but no disruption of the other hypersensitivity sites. (J:94039)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr169 Mutation:	0 strains or lines available

Original:	J:94039 Ansel KM, et al., Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol. 2004 Dec;5(12):1251-9
All:	2 reference(s)