Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fcgrttm1Dcr
Name:	Fc fragment of IgG receptor and transporter; targeted mutation 1, Derry C Roopenian
MGI ID:	MGI:3511510
Synonyms:	FcRn-
Gene:	Fcgrt  Location: Chr7:44742417-44753246 bp, - strand  Genetic Position: Chr7, 29.12 cM
Alliance:	Fcgrttm1Dcr page

Germline Transmission:	Earliest citation of germline transmission: J:94189
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence from exon 1 and part of exon2 was replaced with a PGK-neo cassette. Quantitative PCR of liver cDNA indicated the absence of mRNA. Western blot analysis of neonatal intestinal extracts failed to reveal protein product. (J:94189)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 22 strains available      Cell Lines: 0 lines available
Carrying any Fcgrt Mutation:	60 strains or lines available

Original:	J:94189 Roopenian DC, et al., The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs. J Immunol. 2003 Apr 1;170(7):3528-33
All:	78 reference(s)