Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lattm4.1Mal
Name:	linker for activation of T cells; targeted mutation 4.1, Bernard Malissen
MGI ID:	MGI:3510782
Synonyms:	Lat-
Gene:	Lat  Location: Chr7:125962996-125968742 bp, - strand  Genetic Position: Chr7, 69.01 cM
Alliance:	Lattm4.1Mal page

Germline Transmission:	Earliest citation of germline transmission: J:94074
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1-12 were removed upon replacement with a loxP flanked neo. The neo was subsequently removed by crossing with deleter mice. Western blot of mutant thymocytes indicated a complete lack of protein. (J:94074)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lat Mutation:	9 strains or lines available

Original:	J:94074 Nunez-Cruz S, et al., LAT regulates gammadelta T cell homeostasis and differentiation. Nat Immunol. 2003 Oct;4(10):999-1008
All:	10 reference(s)