Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hgfactm1Hk
Name:	hepatocyte growth factor activator; targeted mutation 1, Hiroaki Kataoka
MGI ID:	MGI:3497731
Synonyms:	HGFA-
Gene:	Hgfac  Location: Chr5:35198853-35205805 bp, + strand  Genetic Position: Chr5, 17.99 cM
Alliance:	Hgfactm1Hk page

Germline Transmission:	Earliest citation of germline transmission: J:93428
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2-4 were replaced with a neomycin resistance gene by homologous recombination. RT-PCR, Northern blot and Western blot analyses confirmed absence of transcript and protein in mutant livers and colons. (J:93428)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hgfac Mutation:	27 strains or lines available

Original:	J:93428 Itoh H, et al., Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice. Gastroenterology. 2004 Dec;127(5):1423-35
All:	3 reference(s)