Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dppa3tm1Dcp
Name:	developmental pluripotency-associated 3; targeted mutation 1, David C Page
MGI ID:	MGI:3057184
Synonyms:	Dppa3-, Dppa3tm1WHT
Gene:	Dppa3  Location: Chr6:122603383-122607230 bp, + strand  Genetic Position: Chr6, 57.72 cM
Alliance:	Dppa3tm1Dcp page

Germline Transmission:	Earliest citation of germline transmission: J:93295
Parent Cell Line:	v6.4 (ES Cell)
Strain of Origin:	(C57BL/6J x 129S4/SvJae)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire coding region was replaced by a floxed hygromycin-thymidine kinase cassette. Transient cre expression in ES cells excised the cassette, leaving a single loxp site and the non-coding portion of the gene. RT-PCR of mutant ovaries demonstrated a lack of transcript. (J:93295)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dppa3 Mutation:	22 strains or lines available

Original:	J:93295 Bortvin A, et al., Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice. BMC Dev Biol. 2004 Mar 23;4(1):2
All:	1 reference(s)