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Hmx3/Hmx2tm3Tlu
Targeted Allele Detail
Summary
Symbol: Hmx3/Hmx2tm3Tlu
Name: H6 homeobox 3; targeted mutation 3, Thomas Lufkin
MGI ID: MGI:3055500
Synonyms: Hmx2-;Hmx3-
Gene: Hmx3  Location: Chr7:131144596-131146654 bp, + strand  Genetic Position: Chr7, 74.32 cM
Alliance: Hmx3/Hmx2tm3Tlu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92940
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsA targeting vector was designed to replace an 11kb genomic fragment encompassing the Hmx2 and Hmx3 homeoboxes with a neomycin resistance gene. The only potential protein to be translated would be a truncated Hmx3 protein lacking the C-terminal portion essential for DNA-binding. (J:92940)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hmx3 Mutation:  15 strains or lines available
Notes
ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+) or D3 (129S2/SvPas).
References
Original:  J:92940 Wang W, et al., Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx. Dev Cell. 2004 Sep;7(3):439-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory