Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tcirg1tm1Utku
Name:	T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3; targeted mutation 1, Nalan Utku
MGI ID:	MGI:3054898
Synonyms:	TIRC7-
Gene:	Tcirg1  Location: Chr19:3946050-3957133 bp, - strand  Genetic Position: Chr19, 3.62 cM
Alliance:	Tcirg1tm1Utku page

Germline Transmission:	Earliest citation of germline transmission: J:92730
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2-8 were replaced with a neomycin resistance gene. Absence of protein was confirmed in T lymphocytes by antibody staining. (J:92730)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcirg1 Mutation:	35 strains or lines available

Original:	J:92730 Utku N, et al., TIRC7 deficiency causes in vitro and in vivo augmentation of T and B cell activation and cytokine response. J Immunol. 2004 Aug 15;173(4):2342-52
All:	1 reference(s)