Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tnfrsf13ctm1Mass
Name:	tumor necrosis factor receptor superfamily, member 13c; targeted mutation 1, Marc Schmidt-Supprian
MGI ID:	MGI:3054891
Synonyms:	Baff-r-, BAFFR-
Gene:	Tnfrsf13c  Location: Chr15:82105944-82108570 bp, - strand  Genetic Position: Chr15, 38.56 cM
Alliance:	Tnfrsf13ctm1Mass page

Germline Transmission:	Earliest citation of germline transmission: J:92732
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Cre-recombinase excised a floxed region containing exons 3 and 4. The excised region encoded the entire extracellular and transmembrane domains and part of the cytoplasmic domain. RT-PCR did not detect mRNA in mutants. FACS analysis showed no surface expression of mutant splenic cells. (J:92732)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfrsf13c Mutation:	14 strains or lines available

Original:	J:92732 Sasaki Y, et al., TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology. J Immunol. 2004 Aug 15;173(4):2245-52
All:	26 reference(s)