Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bhlhe23tm1Dbra
Name:	basic helix-loop-helix family, member e23; targeted mutation 1, Debra E Bramblett
MGI ID:	MGI:3054837
Synonyms:	Bhlhb4-
Gene:	Bhlhe23  Location: Chr2:180416174-180418693 bp, - strand  Genetic Position: Chr2, 103.34 cM, cytoband H3-H4
Alliance:	Bhlhe23tm1Dbra page

Germline Transmission:	Earliest citation of germline transmission: J:92623
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace the entire gene with an IRES-LacZ/PGK-neo cassette. In situ hybridization indicated a lack of mRNA in mutant brain and retina. (J:92623)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bhlhe23 Mutation:	8 strains or lines available

Original:	J:92623 Bramblett DE, et al., The transcription factor bhlhb4 is required for rod bipolar cell maturation. Neuron. 2004 Sep 16;43(6):779-93
All:	3 reference(s)