Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prkacatm2Gsm
Name:	protein kinase, cAMP dependent, catalytic, alpha; targeted mutation 2, G Stanley McKnight
MGI ID:	MGI:3054825
Gene:	Prkaca  Location: Chr8:84699622-84723072 bp, + strand  Genetic Position: Chr8, 40.22 cM, cytoband C3
Alliance:	Prkacatm2Gsm page

Germline Transmission:	Earliest citation of germline transmission: J:92616
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Disruption caused by insertion of vector   Mutation details: This allele carries a loxP site and a mutation of the translation initiation codon in every reading frame in exon 1b. Western blot confirmed absence of protein in testes and sperm. (J:92616)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkaca Mutation:	22 strains or lines available

Original:	J:92616 Nolan MA, et al., Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13483-8
All:	1 reference(s)