Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prnptm2Tuzi
Name:	prion protein; targeted mutation 2, Nadia L Tuzi
MGI ID:	MGI:3052799
Synonyms:	Prpfl
Gene:	Prnp  Location: Chr2:131751848-131780349 bp, + strand  Genetic Position: Chr2, 64.07 cM
Alliance:	Prnptm2Tuzi page

Germline Transmission:	Earliest citation of germline transmission: J:92302
Parent Cell Line:	H1 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exon 3 remained floxed upon Cre-mediated excision of a floxed neo. PCR confirmed recombination in mice. Northern blot demonstrated that transcription was normal in mice carrying this allele and upon further cre-mediated recombination, trasncription will be abolished. (J:92302)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prnp Mutation:	150 strains or lines available

Original:	J:92302 Tuzi NL, et al., Cre-loxP mediated control of PrP to study transmissible spongiform encephalopathy diseases. Genesis. 2004 Sep;40(1):1-6
All:	5 reference(s)