Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Zic5tm1Jaru
Name:	zinc finger protein of the cerebellum 5; targeted mutation 1, Jun Aruga
MGI ID:	MGI:3052154
Synonyms:	Deltaneo
Gene:	Zic5  Location: Chr14:122696572-122703127 bp, - strand  Genetic Position: Chr14, 65.96 cM, cytoband E5
Alliance:	Zic5tm1Jaru page

Germline Transmission:	Earliest citation of germline transmission: J:92220
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to delete 2.3 kb of exon one containing the ATG and encoding three of the five zinc finger motifs. A floxed neo replaced the sequence and was subsequently excised by crossing with mice expressing Cre in the germ line. Immunohistochemistry of mutant hindbrain samples showed no significant immunoreactivity. (J:92220)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zic5 Mutation:	36 strains or lines available

Original:	J:92220 Inoue T, et al., Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives. Dev Biol. 2004 Jun 1;270(1):146-62
All:	1 reference(s)