Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Hrtm1Cct Name: lysine demethylase and nuclear receptor corepressor; targeted mutation 1, Catherine C Thompson MGI ID: MGI:3052135 Synonyms: Hr- Gene: Hr  Location: Chr14:70789652-70810988 bp, + strand  Genetic Position: Chr14, 36.32 cM Alliance: Hrtm1Cct page

Characterization of the Hrtm1Cct/Hrtm1Cct mouse Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:92053
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 8-10 were replaced with a floxed PGK-neo cassette. Southern blot confirmed recombination in mutant mice. Northern blot of mutant skin indicated lack of full-length mRNA and Western blot showed a lack of full-length protein in the skin of mutants. (J:92053)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hr Mutation:	84 strains or lines available

Original:	J:92053 Zarach JM, et al., The co-repressor hairless has a role in epithelial cell differentiation in the skin. Development. 2004 Sep;131(17):4189-200
All:	3 reference(s)