Crb1tm1Wij
Targeted Allele Detail
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Symbol: |
Crb1tm1Wij |
Name: |
crumbs family member 1, photoreceptor morphogenesis associated; targeted mutation 1, Jan Wijnholds |
MGI ID: |
MGI:3052072 |
Synonyms: |
Crb1-, Crb1ex1 |
Gene: |
Crb1 Location: Chr1:139124794-139304838 bp, - strand Genetic Position: Chr1, 60.87 cM
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Alliance: |
Crb1tm1Wij page
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Germline Transmission: |
Earliest citation of germline transmission:
J:92068
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Modified isoform(s)) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A hygromycin resistance cassette replaced 2.9 kb of the upstream promoter region, exon 1 and part of intron 1. Southern blot confirmed a smaller product size and immunoprecipitation indicated no detectable protein. However, LrCaptureSeq data indicates that deletion of this region disrupts isoforms A, A2, and C but leaves isoform B intact.
(J:92068, J:293375)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Crb1 Mutation: |
87 strains or lines available
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Original: |
J:92068 Van De Pavert SA, et al., Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. J Cell Sci. 2004 Aug 15;117(Pt 18):4169-77 |
All: |
15 reference(s) |
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