Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	St8sia2tm1Jxm
Name:	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; targeted mutation 1, Jamey Marth
MGI ID:	MGI:3051219
Synonyms:	St8sia-II-
Gene:	St8sia2  Location: Chr7:73588867-73663408 bp, - strand  Genetic Position: Chr7, 42.27 cM
Alliance:	St8sia2tm1Jxm page

Germline Transmission:	Earliest citation of germline transmission: J:91777
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 4, encoding a significant portion of the sailyl motif L, was deleted upon Cre mediated deletion of the floxed region including the exon and a tk-neo cassette. Southern blot confirmed recombination and RT-PCR indicated that the truncated form of mRNA was produced in heterozygous and homozygous mutants. The mutant cDNA was found to be inactive. (J:91777)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any St8sia2 Mutation:	23 strains or lines available

Original:	J:91777 Angata K, et al., Sialyltransferase ST8Sia-II assembles a subset of polysialic acid that directs hippocampal axonal targeting and promotes fear behavior. J Biol Chem. 2004 Jul 30;279(31):32603-13
All:	29 reference(s)