Mmp14tm1Noda
Targeted Allele Detail
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| Symbol: |
Mmp14tm1Noda |
| Name: |
matrix metallopeptidase 14 (membrane-inserted); targeted mutation 1, Makoto Noda |
| MGI ID: |
MGI:3046860 |
| Synonyms: |
MT1-MMP-, MT1-MMP KO |
| Gene: |
Mmp14 Location: Chr14:54669055-54679913 bp, + strand Genetic Position: Chr14, 27.79 cM
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| Alliance: |
Mmp14tm1Noda page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:91198
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The allele was created with a targeting vector replacing and disrupting exons 1-5, which encode the catlytic domain, with a gene encoding LacZ fused to a nuclear localizing signal. The PGK-gpt/neomycin-resistance gene cassette was inserted in the reverse direction, downstrem of lacZ. Northern blot analysis of homozygous mutant fibroblasts show no detectable mRNA and absence of protein was demonstrated in Western blot of mutant embryos.
(J:91198, J:158339)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Mmp14 Mutation: |
43 strains or lines available
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| Original: |
J:91198 Oh J, et al., Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice. Oncogene. 2004 Jun 24;23(29):5041-8 |
| All: |
9 reference(s) |
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Analysis Tools
