Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Otx2tm5Sia
Name:	orthodenticle homeobox 2; targeted mutation 5, Shinichi Aizawa
MGI ID:	MGI:3046839
Synonyms:	Otx2deltaFM
Gene:	Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Alliance:	Otx2tm5Sia page

Germline Transmission:	Earliest citation of germline transmission: J:91011
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Hypomorph, Modified regulatory region) Mutations:    Insertion, Intragenic deletion   Mutation details: The FM enhancer region (1.4 kb) was replaced with a floxed neomycin-resistance gene. Southern blot and PCR confirmed recombination. Gene expression was shown to be diminished. (J:91011)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:	50 strains or lines available

Original:	J:91011 Kurokawa D, et al., Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development. 2004 Jul;131(14):3319-31
All:	2 reference(s)