Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ungtm1Mend
Name:	uracil DNA glycosylase; targeted mutation 1, Matthias Endres
MGI ID:	MGI:3046503
Synonyms:	Ung-
Gene:	Ung  Location: Chr5:114268447-114277384 bp, + strand  Genetic Position: Chr5, 55.97 cM, cytoband F
Alliance:	Ungtm1Mend page

Germline Transmission:	Earliest citation of germline transmission: J:90910
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1 - 3 and part of exon 4 were replaced with a neo cassette via homologous recombination. RT-PCR indicated that a transcript consisting of exons 1a and 6 is produced, however activity assays confirmed the absence of activity in homozygous cells. (J:90910)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ung Mutation:	23 strains or lines available

Original:	J:90910 Endres M, et al., Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. J Clin Invest. 2004 Jun;113(12):1711-21
All:	15 reference(s)