Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Isl2tm2Slp
Name:	insulin related protein 2 (islet 2); targeted mutation 2, Samuel L Pfaff
MGI ID:	MGI:3046260
Synonyms:	Isl2-
Gene:	Isl2  Location: Chr9:55445956-55453464 bp, + strand  Genetic Position: Chr9, 30.13 cM, cytoband C
Alliance:	Isl2tm2Slp page

Germline Transmission:	Earliest citation of germline transmission: J:89755
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4, 5, and 6, which encode the homeodomain and C terminus were replaced with a neomycin resistance cassette. No protein could be detected in homozygous embryos. (J:89755)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Isl2 Mutation:	28 strains or lines available

Original:	J:89755 Thaler JP, et al., A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity. Neuron. 2004 Feb 5;41(3):337-50
All:	5 reference(s)