Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pcyt1btm1Mkar
Name:	phosphate cytidylyltransferase 1, choline, beta isoform; targeted mutation 1, Muhammad A Karim
MGI ID:	MGI:3045401
Synonyms:	CCTB2-, CCTbeta2-
Gene:	Pcyt1b  Location: ChrX:92698469-92793557 bp, + strand  Genetic Position: ChrX, 41.28 cM
Alliance:	Pcyt1btm1Mkar page

Germline Transmission:	Earliest citation of germline transmission: J:90150
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neo was inserted into exon 2, and a portion of the 3' coding sequence of exon 2 was deleted in the beta2 isoform. Northern blot indicated absence of transcript in brain, liver, lung, testes and ovaries of mutant mice. (J:90150)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pcyt1b Mutation:	86 strains or lines available

Original:	J:90150 Jackowski S, et al., Disruption of CCT{beta}2 Expression Leads to Gonadal Dysfunction. Mol Cell Biol. 2004 Jun;24(11):4720-4733
All:	3 reference(s)