Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol: Map3k4tm1Flv Name: mitogen-activated protein kinase kinase kinase 4; targeted mutation 1, Richard A Flavell MGI ID: MGI:3044978 Synonyms: MEKK4- Gene: Map3k4  Location: Chr17:12446508-12537683 bp, - strand  Genetic Position: Chr17, 8.42 cM Alliance: Map3k4tm1Flv page

XY gonad in Map3k4tm1Flv/Map3k4tm1Flv embryos exhibits overt ovarian morphology Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:90112
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted 5' to exon 3 and a floxed neomycin resistance cassette was placed 3' to the exon. Chimeric male mice were bred to female mice carrying Tg(Tek-cre)12Flv to delete exon 3 and the neomycin resistance gene. This removes the entire GADD45-binding domain and causes a frame shift and premature termination. Absence of protein was confirmed by Western blot analysis. (J:90112)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	69 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Map3k4 Mutation:	77 strains or lines available

Original:	J:90112 Chi H, et al., GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. EMBO J. 2004 Apr 7;23(7):1576-86
All:	8 reference(s)