Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mfge8tm1Osa
Name:	milk fat globule EGF and factor V/VIII domain containing; targeted mutation 1, Shigekazu Nagata
MGI ID:	MGI:3044898
Synonyms:	MFG-E8-
Gene:	Mfge8  Location: Chr7:78783516-78798808 bp, - strand  Genetic Position: Chr7, 44.9 cM
Alliance:	Mfge8tm1Osa page

Germline Transmission:	Earliest citation of germline transmission: J:90633
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomysin resistance cassette replaced exons 4-6. Southern blot confirmed recombination in mutant tails. Western blot analysis showed no protein expression in macrophages. (J:90633)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mfge8 Mutation:	23 strains or lines available

Original:	J:90633 Hanayama R, et al., Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science. 2004 May 21;304(5674):1147-50
All:	37 reference(s)