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Rgs1tm1Jhk
Targeted Allele Detail
Summary
Symbol: Rgs1tm1Jhk
Name: regulator of G-protein signaling 1; targeted mutation 1, John H Kehrl
MGI ID: MGI:3044786
Synonyms: Rgs1-
Gene: Rgs1  Location: Chr1:144120407-144124862 bp, - strand  Genetic Position: Chr1, 62.56 cM
Alliance: Rgs1tm1Jhk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90780
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neo gene was inserted into exon 1 via homologous recombination disrupting the first coding exon and exon splice donor site. Immunoblotting of B-cell lysates after immunization confirmed the absence of protein expression in homozygous mice. Expression of clustered and related Rgs genes was unaffected. (J:90780)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rgs1 Mutation:  23 strains or lines available
References
Original:  J:90780 Moratz C, et al., Abnormal B-cell responses to chemokines, disturbed plasma cell localization, and distorted immune tissue architecture in Rgs1-/- mice. Mol Cell Biol. 2004 Jul;24(13):5767-75
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory