Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	H2-T23tm1Cant
Name:	histocompatibility 2, T region locus 23; targeted mutation 1, Harvey Cantor
MGI ID:	MGI:3044027
Synonyms:	Qa-1-, Qa-1b-, Qa-1 KO
Gene:	H2-T23  Location: Chr17:36340869-36343593 bp, - strand  Genetic Position: Chr17, 18.86 cM
Alliance:	H2-T23tm1Cant page

Germline Transmission:	Earliest citation of germline transmission: J:89808
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1 - 3 were replaced with a neo cassette via homologous recombination. This insertion introduced a frameshift. The absence of protein expression in activated thymocytes and splenic T cells was confirmed by flow cytometry. (J:89808)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any H2-T23 Mutation:	35 strains or lines available

Original:	J:89808 Hu D, et al., Analysis of regulatory CD8 T cells in Qa-1-deficient mice. Nat Immunol. 2004 Jun;5(5):516-23
All:	22 reference(s)