Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mbl1tm1Kata
Name:	mannose-binding lectin (protein A) 1; targeted mutation 1, Kazue Takahashi
MGI ID:	MGI:3043898
Synonyms:	MBL-A-
Gene:	Mbl1  Location: Chr14:40873415-40881558 bp, + strand  Genetic Position: Chr14, 22.36 cM
Alliance:	Mbl1tm1Kata page

Germline Transmission:	Earliest citation of germline transmission: J:90437
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 5 was disrupted by the insertion of a neomycin selection cassette into sequence encoding the carbohydrate recognition domain. Transcript was undetected by RT-PCR analysis of liver RNA obtained from homozygous mutant mice. RT-PCR analysis indicated that transcription of the paralogous Mbl2 gene was unaffected. (J:90437)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mbl1 Mutation:	23 strains or lines available

Original:	J:90437 Takahashi K, et al., Lack of mannose-binding lectin-A enhances survival in a mouse model of acute septic peritonitis. Microbes Infect. 2002 Jul;4(8):773-84
All:	60 reference(s)