Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Asic2tm1.1Lzd
Name:	acid-sensing ion channel 2; targeted mutation 1.1, Michel Lazdunski
MGI ID:	MGI:3043849
Synonyms:	ASIC-, ASIC2-
Gene:	Asic2  Location: Chr11:80770989-81859222 bp, - strand  Genetic Position: Chr11, 48.43 cM
Alliance:	Asic2tm1.1Lzd page

Germline Transmission:	Earliest citation of germline transmission: J:90117
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: This allele was derived by crossing Accn1tm1Lzd mice with mice expressing Cre recombinase under the control of a cytomegalovirus promoter. This resulted in the excision of the exon encoding the second transmembrane domain causing a frameshift and truncating both known splice varients. Truncated mRNA was detectable by in situ hybridization but truncated protein was virtually absent. (J:90117)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Asic2 Mutation:	35 strains or lines available

Original:	J:90117 Ettaiche M, et al., Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration. J Neurosci. 2004 Feb 4;24(5):1005-12
All:	3 reference(s)