Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc6a18tm1Mca
Name:	solute carrier family 6 (neurotransmitter transporter), member 18; targeted mutation 1, Marc G Caron
MGI ID:	MGI:3043846
Synonyms:	XT2-/-
Gene:	Slc6a18  Location: Chr13:73809871-73826142 bp, - strand  Genetic Position: Chr13, 40.13 cM
Alliance:	Slc6a18tm1Mca page

Germline Transmission:	Earliest citation of germline transmission: J:89891
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A single loxP site remained in place of a genomic fragment encompassing exon 1 and a portion of intron 1 after a floxed neo cassette was excised via cre-mediated recombination. Absence of mRNA expression in homozygous mutant mice was verified by RT-PCR analysis. (J:89891)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a18 Mutation:	32 strains or lines available

Original:	J:89891 Quan H, et al., Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2. Mol Cell Biol. 2004 May;24(10):4166-73
All:	2 reference(s)