Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Anp32atm1Hzo
Name:	acidic nuclear phosphoprotein 32 family member A; targeted mutation 1, Huda Y Zoghbi
MGI ID:	MGI:3043774
Synonyms:	Lanp-
Gene:	Anp32a  Location: Chr9:62248637-62286084 bp, + strand  Genetic Position: Chr9, 33.68 cM
Alliance:	Anp32atm1Hzo page

Germline Transmission:	Earliest citation of germline transmission: J:89899
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of eoxn 2. A floxed neo cassette was inserted downstream of exon 3. Cre-mediated recombination removed exon 2, exon 3, and the neo cassette. Aberrant splicing between exons 1 and 4 is predicted to produce a premature stop codon in exon 4 due to a frameshift. The absence of protein expression was confirmed by western blot analysis of cerebellar extracts. (J:89899)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Anp32atm1Hzo

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Anp32a Mutation:	56 strains or lines available

Original:	J:89899 Opal P, et al., Generation and characterization of LANP/pp32 null mice. Mol Cell Biol. 2004 Apr;24(8):3140-9
All:	6 reference(s)