Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Ercc5tm2Shm
Name:	excision repair cross-complementing rodent repair deficiency, complementation group 5; targeted mutation 2, Tadahiro Shiomi
MGI ID:	MGI:3043588
Synonyms:	Xpg-delta-ex15
Gene:	Ercc5  Location: Chr1:44186904-44220420 bp, + strand  Genetic Position: Chr1, 23.55 cM, cytoband B
Alliance:	Ercc5tm2Shm page

Germline Transmission:	Earliest citation of germline transmission: J:89911
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 15 was replaced with an MC1-neo cassette via homologous recombination. This C-terminal truncation removed the last 183 amino acids. Northern analysis detected 2 large mRNA's with 6 or 36 amino acids incorporated after exon 14 but lacking exon 15. (J:89911)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ercc5 Mutation:	55 strains or lines available

Original:	J:89911 Shiomi N, et al., Identification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in method. Mol Cell Biol. 2004 May;24(9):3712-9
All:	2 reference(s)