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Frmpd4 Gene Detail
Summary
  • Symbol
    Frmpd4
  • Name
    FERM and PDZ domain containing 4
  • Synonyms
    LOC237234, Pdzd10, Pdzk10, PKAP1, Preso, Preso1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3042378
    NCBI Gene: 333605
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:166254305-167360227 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 78.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2997 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3042378
 protein coding gene ChrX:166254297-167360230 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036273
 protein coding gene ChrX:165640334-166780689 (-)
A/J MGP_AJ_G0036242
 protein coding gene ChrX:164780058-165914740 (-)
AKR/J MGP_AKRJ_G0036172
 protein coding gene ChrX:170057923-171221825 (-)
BALB/cJ MGP_BALBcJ_G0036237
 protein coding gene ChrX:162727901-163881659 (-)
C3H/HeJ MGP_C3HHeJ_G0035944
 protein coding gene ChrX:165955436-167088106 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036760
 protein coding gene ChrX:170460701-171618455 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033580
 protein coding gene ChrX:155572987-156632876 (-)
CAST/EiJ MGP_CASTEiJ_G0035231
 protein coding gene ChrX:144832812-145950076 (-)
CBA/J MGP_CBAJ_G0035918
 protein coding gene ChrX:175422220-176612967 (-)
DBA/2J MGP_DBA2J_G0036084
 protein coding gene ChrX:163582663-164682304 (-)
FVB/NJ MGP_FVBNJ_G0036016
 protein coding gene ChrX:162729108-163820833 (-)
LP/J MGP_LPJ_G0036169
 protein coding gene ChrX:166717946-167870100 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0036048
 protein coding gene ChrX:184098119-185334804 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036799
 protein coding gene ChrX:165102032-166238905 (-)
PWK/PhJ MGP_PWKPhJ_G0034930
 protein coding gene ChrX:141557098-142679223 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034749
 protein coding gene ChrX:145380605-145659202 (-)
WSB/EiJ MGP_WSBEiJ_G0035367
 protein coding gene ChrX:162940910-164049586 (-)



Homology
more
  • Human Ortholog
    FRMPD4, FERM and PDZ domain containing 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FRMPD4, FERM and PDZ domain containing 4
  • Synonyms
    MRX104, PDZD10, PDZK10, XLID104
  • Links
    NCBI Gene ID: 9758
    neXtProt AC: NX_Q14CM0
    UniProt: Q14CM0

  • Chr Location
    Xp22.2; chrX:11822423-12724523 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FRMPD4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased inflammation-induced pain and thermal pain in a chronic pain model.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    5
  • cDNA Data
    10
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049176 Ensembl Gene Model | MGI Sequence Detail 1105923 C57BL/6J ±  kb
transcript ENSMUST00000238709 Ensembl | MGI Sequence Detail 5337 Not Applicable  
polypeptide ENSMUSP00000158713 Ensembl | MGI Sequence Detail 1778 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 1
Other
Accession IDs
less
MGI:2685042
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:333383 Funk OH, et al., Postmitotic accumulation of histone variant H3.3 in new cortical neurons establishes neuronal chromatin, transcriptome, and identity. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2116956119
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory