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Traf7 Gene Detail
Summary
  • Symbol
    Traf7
  • Name
    TNF receptor-associated factor 7
  • Synonyms
    RFWD1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3042141
    NCBI Gene: 224619
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24727824-24746912 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3042141
 protein coding gene Chr17:24727536-24746912 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023305
 protein coding gene Chr17:23497669-23519409 (-)
A/J MGP_AJ_G0023265
 protein coding gene Chr17:22864648-22885029 (-)
AKR/J MGP_AKRJ_G0023232
 protein coding gene Chr17:22940117-22961646 (-)
BALB/cJ MGP_BALBcJ_G0023270
 protein coding gene Chr17:23051509-23071339 (-)
C3H/HeJ MGP_C3HHeJ_G0023030
 protein coding gene Chr17:23298064-23318990 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023714
 protein coding gene Chr17:24549505-24570533 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021190
 protein coding gene Chr17:20329598-20340423 (-)
CAST/EiJ MGP_CASTEiJ_G0022532
 protein coding gene Chr17:23136056-23158469 (-)
CBA/J MGP_CBAJ_G0023006
 protein coding gene Chr17:25380978-25407736 (-)
DBA/2J MGP_DBA2J_G0023135
 protein coding gene Chr17:22450906-22473861 (-)
FVB/NJ MGP_FVBNJ_G0023105
 protein coding gene Chr17:22173516-22192821 (-)
LP/J MGP_LPJ_G0023212
 protein coding gene Chr17:23809386-23830622 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023124
 protein coding gene Chr17:25101606-25122263 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023751
 protein coding gene Chr17:23219373-23238855 (-)
PWK/PhJ MGP_PWKPhJ_G0022281
 protein coding gene Chr17:21203219-21223037 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022100
 protein coding gene Chr17:21252310-21274912 (-)
WSB/EiJ MGP_WSBEiJ_G0022595
 protein coding gene Chr17:23286322-23306722 (-)



Homology
more
  • Human Ortholog
    TRAF7, TNF receptor associated factor 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRAF7, TNF receptor associated factor 7
  • Synonyms
    CAFDADD, RFWD1, RNF119
  • Links
    NCBI Gene ID: 84231
    neXtProt AC: NX_Q6Q0C0
    UniProt: Q6Q0C0

  • Chr Location
    16p13.3; chr16:2155698-2178129 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human TRAF7 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    16
  • cDNA Data
    134
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224619 NCBI Gene Model | MGI Sequence Detail 19089 C57BL/6J ±  kb
    transcript NM_153792 RefSeq | MGI Sequence Detail 2735 C57BL/6  
    polypeptide Q922B6 UniProt | EBI | MGI Sequence Detail 594 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 134
      cDNA 134

      Microarray probesets 2
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:89527 Xu LG, et al., TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J Biol Chem. 2004 Apr 23;279(17):17278-82
    • Latest
      J:339061 Tsitsikov EN, et al., TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal development. iScience. 2023 Aug 18;26(8):107474
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory