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Mapk3tm1Gela
Targeted Allele Detail
Summary
Symbol: Mapk3tm1Gela
Name: mitogen-activated protein kinase 3; targeted mutation 1, Gary E Landreth
MGI ID: MGI:3042006
Synonyms: ERK1 -, Mapk3tm1Jsw, Mapk3tm1Tgf
Gene: Mapk3  Location: Chr7:126358798-126364988 bp, + strand  Genetic Position: Chr7, 69.25 cM
Alliance: Mapk3tm1Gela page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77455
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Not Specified
 
Mutation detailsA targeting construct was designed to replace exons 1-6 of the protein coding sequence, including protein kinase domains I-X, with a neomycin resistance gene flanked by loxP sites. The null allele was confirmed by Western blot analysis. (J:77455, J:107504)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
Tumor Data
List all tumor models in MMHCdb carrying Mapk3tm1Gela
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapk3 Mutation:  26 strains or lines available
References
Original:  J:77455 Selcher JC, et al., Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning. Learn Mem. 2001 Jan-Feb;8(1):11-9
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory