Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ppargtm1.1Mtz
Name:	peroxisome proliferator activated receptor gamma; targeted mutation 1.1, Daniel Metzger
MGI ID:	MGI:3041450
Synonyms:	PPARgammaL-, Ppargdelta
Gene:	Pparg  Location: Chr6:115337912-115467360 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Alliance:	Ppargtm1.1Mtz page

Germline Transmission:	Earliest citation of germline transmission: J:89238
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre-mediated recombination of Ppargtm1Mtz excised the sequence between the most 5' and 3' LoxP sites, removing exons 1 and 2 and the floxed neo. Exon 1 contains the initiator methionine codon for the gamma 1 isoform and exon 2 encodes the first zinc finger of the DNA-binding domain for gamma 1 and gamma 2 isoforms. PCR confirmed recombination. (J:89238)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:	39 strains or lines available

Original:	J:89238 Imai T, et al., Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci U S A. 2004 Apr 30;101(13):4543-7
All:	7 reference(s)