Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Ticam2tm1Aki
Name:	TIR domain containing adaptor molecule 2; targeted mutation 1, Shizuo Akira
MGI ID:	MGI:3040182
Synonyms:	Ticam2-, Tram_, TRAM-
Gene:	Ticam2  Location: Chr18:46691298-46707600 bp, - strand  Genetic Position: Chr18, 24.65 cM
Alliance:	Ticam2tm1Aki page

Germline Transmission:	Earliest citation of germline transmission: J:86256
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1.0 kb fragment encompassing the entire coding region of this single-exon gene was replaced with a neomycin selection cassette. Protein was undetected by Western blot analysis of immunoprecipitated lysates from homozygous mutant macrophages. (J:86256)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ticam2 Mutation:	21 strains or lines available

Original:	J:86256 Yamamoto M, et al., TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol. 2003 Nov;4(11):1144-50
All:	24 reference(s)