Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mapk7tm1.1Jdl
Name:	mitogen-activated protein kinase 7; targeted mutation 1.1, Jiing-Dwan Lee
MGI ID:	MGI:3040181
Synonyms:	BMK1-CKO
Gene:	Mapk7  Location: Chr11:61379638-61385101 bp, - strand  Genetic Position: Chr11, 37.96 cM
Alliance:	Mapk7tm1.1Jdl page

Germline Transmission:	Earliest citation of germline transmission: J:89215
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Floxed exons 4-7 in Mapk7tm1Jdl were removed by Cre-mediated recombination, leaving a single loxP site. These exons encode for the kinase domain and the unique C-terminal nonkinase region of the protein. Western blot of homozygous mutant livers confirmed absence of protein. (J:89215)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapk7 Mutation:	32 strains or lines available

Original:	J:89215 Hayashi M, et al., Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J Clin Invest. 2004 Apr;113(8):1138-48
All:	1 reference(s)