Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Card11tm1Litt
Name:	caspase recruitment domain family, member 11; targeted mutation 1, Dan R Littman
MGI ID:	MGI:3039682
Synonyms:	CARMA1-, carma1FN
Gene:	Card11  Location: Chr5:140858745-140986337 bp, - strand  Genetic Position: Chr5, 79.42 cM
Alliance:	Card11tm1Litt page

Germline Transmission:	Earliest citation of germline transmission: J:89322
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A single loxP site was inserted into intron 2 and a loxP-flanked neomycin selection cassette was inserted into intron 4 through homologous recombination. Western blot analysis on extracts derived from splenocytes of homozygous mice confirmed that no detectable protein was expressed from this allele. (J:89322)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Card11 Mutation:	58 strains or lines available

Original:	J:89322 Egawa T, et al., Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol. 2003 Jul 15;13(14):1252-8
All:	11 reference(s)