Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Atp8b3tm1Gar
Name:	ATPase, class I, type 8B, member 3; targeted mutation 1, David L Garbers
MGI ID:	MGI:3039498
Synonyms:	SAPLT-
Gene:	Atp8b3  Location: Chr10:80355418-80374958 bp, - strand  Genetic Position: Chr10, 39.72 cM, cytoband C1
Alliance:	Atp8b3tm1Gar page

Germline Transmission:	Earliest citation of germline transmission: J:88796
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment encompassing exons 4 through 14 was replaced with a neomycin selection cassette. The deleted region encoded the first four transmembrane domains of the protein. No protein was detected in homozygous mutant mice by Western blot analysis of testes membrane extracts or by immunostaining of spermatozoa. (J:88796)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atp8b3 Mutation:	60 strains or lines available

Original:	J:88796 Wang L, et al., A novel aminophospholipid transporter exclusively expressed in spermatozoa is required for membrane lipid asymmetry and normal fertilization. Dev Biol. 2004 Mar 1;267(1):203-15
All:	1 reference(s)