Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Llgl1tm1.1Vv
Name:	LLGL1 scribble cell polarity complex component; targeted mutation 1.1, Valeri Vasioukhin
MGI ID:	MGI:3039269
Synonyms:	Lgl1-
Gene:	Llgl1  Location: Chr11:60590549-60605012 bp, + strand  Genetic Position: Chr11, 37.81 cM
Alliance:	Llgl1tm1.1Vv page

Germline Transmission:	Earliest citation of germline transmission: J:89028
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The floxed exon in Llglhtm1Vv was removed via cre-mediated recombination, leaving a single LoxP site in its place. The deletion resulted in a frame shift in translation of the protein, which is predicted to disrupt translation after the first 27 amino acids that do not encode any known domains. Western blot analysis from mutants showed no protein was present. (J:89028)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Llgl1 Mutation:	63 strains or lines available

Original:	J:89028 Klezovitch O, et al., Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Genes Dev. 2004 Mar 1;18(5):559-71
All:	5 reference(s)