Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Gad2tm1Miya
Name:	glutamic acid decarboxylase 2; targeted mutation 1, Jun-ichi Miyazaki
MGI ID:	MGI:3038621
Synonyms:	GAD65-
Gene:	Gad2  Location: Chr2:22512262-22583889 bp, + strand  Genetic Position: Chr2, 15.15 cM, cytoband A-B
Alliance:	Gad2tm1Miya page

Germline Transmission:	Earliest citation of germline transmission: J:88785
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: An in frame translational stop codon was inserted in exon 2 by homologous recombination. Absence of Gad2 mRNA and protein in homozygotes was confirmed by Northern and Western blot analysis of brains. (J:88785, J:89181)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gad2 Mutation:	60 strains or lines available

Original:	J:88785 Yamamoto T, et al., Development of autoimmune diabetes in glutamic acid decarboxylase 65 (GAD65) knockout NOD mice. Diabetologia. 2004 Feb;47(2):221-4
All:	7 reference(s)