Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il4/Il13tm3Anjm
Name:	interleukin 13; targeted mutation 3, Andrew NJ McKenzie
MGI ID:	MGI:3038245
Synonyms:	Il-4/13-, Il-4-Il-13-, IL-4/IL-13-
Gene:	Il13  Location: Chr11:53522151-53525529 bp, - strand  Genetic Position: Chr11, 31.98 cM
Alliance:	Il4/Il13tm3Anjm page

Germline Transmission:	Earliest citation of germline transmission: J:89095
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intergenic deletion   Mutation details: Homologous recombination results in the deletion of a 15 kb region from exon 3 of the Il13 locus to intron 3 of the Il4 locus. RT-PCR and ELISAs failed to detect any Il4 or Il13 mRNA in activated lymphocytes or protein in stimulated CD4+ T-cells. (J:89095)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il13 Mutation:	29 strains or lines available

Original:	J:89095 McKenzie GJ, et al., Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. J Exp Med. 1999 May 17;189(10):1565-72
All:	72 reference(s)