Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ptafrtm1Tksh
Name:	platelet-activating factor receptor; targeted mutation 1, Takao Shimizu
MGI ID:	MGI:3036770
Synonyms:	pafr-
Gene:	Ptafr  Location: Chr4:132291378-132309994 bp, + strand  Genetic Position: Chr4, 65.56 cM, cytoband D2.2
Alliance:	Ptafrtm1Tksh page

Germline Transmission:	Earliest citation of germline transmission: J:88505
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin cassette was inserted into the open reading frame disrupting this gene. Northern analysis of RNA isolated from neutrophils from homozygotes demonstrated that no detectable transcript is produced from this allele. No antagonist binding was detectable in peritoneal macrophages or lung tissues from homozygotes. (J:88505)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

9 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ptafr Mutation:	20 strains or lines available

Original:	J:88505 Ishii S, et al., Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor. J Exp Med. 1998 Jun 1;187(11):1779-88
All:	59 reference(s)