Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Runx1tm1.1Soga
Name:	runt related transcription factor 1; targeted mutation 1.1, Seishi Ogawa
MGI ID:	MGI:3036557
Synonyms:	Aml1delta, Runx1-
Gene:	Runx1  Location: Chr16:92398354-92622962 bp, - strand  Genetic Position: Chr16, 53.7 cM
Alliance:	Runx1tm1.1Soga page

Germline Transmission:	Earliest citation of germline transmission: J:88511
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A single loxP site was left in place of exon 5 and its flanking sequence after cre-mediated recombination in the germline. (J:88511)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:	35 strains or lines available

Original:	J:88511 Ichikawa M, et al., AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat Med. 2004 Apr;10(3):299-304
All:	3 reference(s)