Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc25a4tm2Dwa
Name:	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4; targeted mutation 2, Douglas C Wallace
MGI ID:	MGI:3036342
Synonyms:	Ant1PGKneo
Gene:	Slc25a4  Location: Chr8:46660205-46664099 bp, - strand  Genetic Position: Chr8, 26.22 cM
Alliance:	Slc25a4tm2Dwa page

Germline Transmission:	Earliest citation of germline transmission: J:41256
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin gene replaced exons 1-3. Northern blot analysis demonstrated the absence of mRNA transcript while protein product was undetectable by Western blot. (J:41256)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc25a4 Mutation:	16 strains or lines available

Original:	J:41256 Graham BH, et al., A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator. Nat Genet. 1997 Jul;16(3):226-34
All:	11 reference(s)