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Trim55 Gene Detail
Summary
  • Symbol
    Trim55
  • Name
    tripartite motif-containing 55
  • Synonyms
    D830041C10Rik, Murf2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036269
    NCBI Gene: 381485
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:19698638-19746585 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 5.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    524 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3036269
 protein coding gene Chr3:19698591-19746748 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027095
 protein coding gene Chr3:16849470-16894170 (+)
A/J MGP_AJ_G0027055
 protein coding gene Chr3:16766680-16819881 (+)
AKR/J MGP_AKRJ_G0027024
 protein coding gene Chr3:16924260-16984609 (+)
BALB/cJ MGP_BALBcJ_G0027067
 protein coding gene Chr3:16528482-16575154 (+)
C3H/HeJ MGP_C3HHeJ_G0026808
 protein coding gene Chr3:16955840-17004938 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027512
 protein coding gene Chr3:17933000-17980300 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024874
 protein coding gene Chr3:14848247-14896966 (+)
CAST/EiJ MGP_CASTEiJ_G0026263
 protein coding gene Chr3:16871401-16916562 (+)
CBA/J MGP_CBAJ_G0026786
 protein coding gene Chr3:18305240-18355361 (+)
DBA/2J MGP_DBA2J_G0026920
 protein coding gene Chr3:16381061-16427280 (+)
FVB/NJ MGP_FVBNJ_G0026888
 protein coding gene Chr3:16039055-16083355 (+)
LP/J MGP_LPJ_G0027032
 protein coding gene Chr3:17497695-17546157 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026909
 protein coding gene Chr3:20385228-20434681 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027571
 protein coding gene Chr3:16688339-16731910 (+)
PWK/PhJ MGP_PWKPhJ_G0025996
 protein coding gene Chr3:16094170-16140323 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025804
 protein coding gene Chr3:16543329-16587648 (+)
WSB/EiJ MGP_WSBEiJ_G0026336
 protein coding gene Chr3:16740992-16783965 (+)



Homology
more
  • Human Ortholog
    TRIM55, tripartite motif containing 55
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM55, tripartite motif containing 55
  • Synonyms
    muRF2, MURF-2, RNF29
  • Links
    NCBI Gene ID: 84675
    neXtProt AC: NX_Q9BYV6
    UniProt: Q9BYV6

  • Chr Location
    8q13.1; chr8:66113351-66175485 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 2 genetic backgrounds
    25 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased heart and muscle to body weight ratios and cardiac hypertrophy. Homozygous mice exhibit reduced severity of symptoms following SARS coronavirus infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    12
  • cDNA Data
    3
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060913 Ensembl Gene Model | MGI Sequence Detail 47948 C57BL/6J ±  kb
    transcript ENSMUST00000029139 Ensembl | MGI Sequence Detail 2595 Not Applicable  
    polypeptide ENSMUSP00000029139 Ensembl | MGI Sequence Detail 545 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 3
      Primer pair 4

      Microarray probesets 1
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory