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Plcl1 Gene Detail
Summary
  • Symbol
    Plcl1
  • Name
    phospholipase C-like 1
  • Synonyms
    C230017K02Rik, PLC-L, PRIP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036262
    NCBI Gene: 227120
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:55445080-55793444 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 28.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3256 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3036262
 protein coding gene Chr1:55442722-55793444 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016036
 protein coding gene Chr1:55126855-55499952 (+)
A/J MGP_AJ_G0016019
 protein coding gene Chr1:53222259-53579042 (+)
AKR/J MGP_AKRJ_G0015975
 protein coding gene Chr1:54669329-55026814 (+)
BALB/cJ MGP_BALBcJ_G0015974
 protein coding gene Chr1:53261720-53627227 (+)
C3H/HeJ MGP_C3HHeJ_G0015806
 protein coding gene Chr1:54910362-55276440 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016427
 protein coding gene Chr1:57415348-57809181 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014148
 protein coding gene Chr1:49308988-49632828 (+)
CAST/EiJ MGP_CASTEiJ_G0015388
 protein coding gene Chr1:54192764-54560539 (+)
CBA/J MGP_CBAJ_G0015778
 protein coding gene Chr1:59069084-59456140 (+)
DBA/2J MGP_DBA2J_G0015879
 protein coding gene Chr1:52656930-53008366 (+)
FVB/NJ MGP_FVBNJ_G0015881
 protein coding gene Chr1:51984533-52329540 (+)
LP/J MGP_LPJ_G0015951
 protein coding gene Chr1:55974241-56349172 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015901
 protein coding gene Chr1:62148647-62524190 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016474
 protein coding gene Chr1:54610679-54989855 (+)
PWK/PhJ MGP_PWKPhJ_G0015174
 protein coding gene Chr1:52002064-52358359 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014955
 protein coding gene Chr1:54232346-54607537 (+)
WSB/EiJ MGP_WSBEiJ_G0015451
 protein coding gene Chr1:54297577-54671276 (+)



Homology
more
  • Human Ortholog
    PLCL1, phospholipase C like 1 (inactive)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLCL1, phospholipase C like 1 (inactive)
  • Synonyms
    PLCE, PLCL, PLDL1, PPP1R127, PRIP
  • Links
    NCBI Gene ID: 5334
    neXtProt AC: NX_Q15111
    UniProt: Q15111

  • Chr Location
    2q33.1; chr2:197804593-198572581 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants display impaired motor coordination and decreased sensitivity to the sedative diazepam.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    854
  • Tissues
    104
  • cDNA Data
    20
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038349 Ensembl Gene Model | MGI Sequence Detail 348365 C57BL/6J ±  kb
    transcript ENSMUST00000042986 Ensembl | MGI Sequence Detail 6580 Not Applicable  
    polypeptide ENSMUSP00000037854 Ensembl | MGI Sequence Detail 1096 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000012840 inactive phospholipase C-like protein 1
      (term hierarchy)
    • InterPro Domains
      IPR000008 C2 domain
      IPR035892 C2 domain superfamily
      IPR011992 EF-hand domain pair
      IPR011993 PH-like domain superfamily
      IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
      IPR001192 Phosphoinositide phospholipase C family
      IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
      IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
      IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
      IPR001849 Pleckstrin homology domain
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 2
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 24
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:327722 Gao J, et al., Phospholipase C-related but catalytically inactive protein acts as a positive regulator of insulin signalling in adipocytes. J Cell Sci. 2022 Jan 1;135(1):jcs258584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory