Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Deaf1tm1Sho
Name:	DEAF1, transcription factor; targeted mutation 1, Stuart Orkin
MGI ID:	MGI:3035918
Synonyms:	Deaf-1-
Gene:	Deaf1  Location: Chr7:140877093-140907603 bp, - strand  Genetic Position: Chr7, 86.61 cM
Alliance:	Deaf1tm1Sho page

Germline Transmission:	Earliest citation of germline transmission: J:88168
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Two exons coding for amino acids 192 to 269 were replaced by a floxed PGK-neomycin resistance cassette. Neomycin was subsequently excised by mating chimeric mice to cre-expressing transgenic mice. (J:88168)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	3 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Deaf1 Mutation:	27 strains or lines available

Original:	J:88168 Hahm K, et al., Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. Mol Cell Biol. 2004 Mar;24(5):2074-82
All:	7 reference(s)