About   Help   FAQ
Hsf1tm1Miv
Targeted Allele Detail
Summary
Symbol: Hsf1tm1Miv
Name: heat shock factor 1; targeted mutation 1, Nahid F Mivechi
MGI ID: MGI:3033933
Synonyms: hsf1-
Gene: Hsf1  Location: Chr15:76361562-76385355 bp, + strand  Genetic Position: Chr15, 35.95 cM
Alliance: Hsf1tm1Miv page
Testes are smaller in Hsf2tm1Miv/Hsf2tm1Miv and Hsf1tm1Miv/Hsf1tm1Miv Hsf2tm1Miv/Hsf2tm1Miv mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88534
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 55 bp segment of exon 2 was replaced with a cassette containing IRES, lacZ, and a floxed PGK-neomycin resistance gene. The DNA binding domain was disrupted and a frame shift was created in the process. A shorter mRNA transcript in which exon 1 is spliced directly to exon 3 was detected by Northern blot analysis. Immunoblot analysis indicated the absence of any protein product. Beta-galactosidase expression was not detected. (J:88534)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsf1 Mutation:  25 strains or lines available
References
Original:  J:88534 Zhang Y, et al., Targeted disruption of hsf1 leads to lack of thermotolerance and defines tissue-specific regulation for stress-inducible Hsp molecular chaperones. J Cell Biochem. 2002;86(2):376-93
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory