Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Dph1tm1Bhr
Name:	diphthamide biosynthesis 1; targeted mutation 1, Richard R Behringer
MGI ID:	MGI:3033421
Synonyms:	Ovca1 -
Gene:	Dph1  Location: Chr11:75068469-75081309 bp, - strand  Genetic Position: Chr11, 45.76 cM
Alliance:	Dph1tm1Bhr page

Germline Transmission:	Earliest citation of germline transmission: J:88090
Parent Cell Line:	PC3 (ES Cell)
Strain of Origin:	129S4/SvJae-Tg(Prm-cre)70Og

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A linker containing stop codons in all three reading frames together with a floxed neomycin resistance cassette were introduced into exon 3. Targeting took place in ES cells homozygous for the Tg(Prm-cre)70Og transgene. Cre-mediated excision subsequently removed the neomycin cassette upon transmission from male chimeric mice. mRNA transcripts were produced but Western blot analysis demonstrated the absence of protein. (J:88090)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

List all tumor models in MMHCdb carrying Dph1tm1Bhr

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dph1 Mutation:	27 strains or lines available

Original:	J:88090 Chen CM, et al., Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis. Genes Dev. 2004 Feb 1;18(3):320-32
All:	3 reference(s)